You can always count on Karen for the best advice!

Will returns home from his trip to find Grace and Jack closer than ever.

In Season 4, Jack bumps his head and has a divine experience.

Jack (Sean Hayes) tries to seduce Bill (Neil Patrick Harris) at a Welcome Back Home gathering for "ex-gay" people. Karen (Megan Mullally) tags along, hoping to make out with a woman.

When Bobbi, Karen and Jack met for the first time, it was pure magic.

Jack makes a confession to his mother, and she makes a confession to him.

Watch the best of Will Truman (Eric McCormack) from Will and Grace and subsequently be jealous about how fast he can think on his feet.

Jack (Sean Hayes), Karen (Megan Mullally) and Rosario (guest star Shelley Morrison) have an interesting visit with an I.N.S. officer (guest star Peter Paige).

Will, Grace, Jack & Karen all hangout at the White House, for very different reasons.

During Season 6, Will and Jack wake up naked next to each other without a clue what happened the night before.

It's everyone's favorite Adler (sorry Grace) - Debbie Reynolds! Guest starring as Grace's mom throughout the series, this musical theatre legend had many a memorable moment - including singing some of her iconic showbiz hits on the show!

Following Ellen’s cancelation, many believed that any primetime show with a gay lead was cursed to fail.

Listen lady! Rosario was ICONIC on Will & Grace.

Jack (Sean Hayes) meets the real Cher while out to lunch with his Cher doll. Unconvinced it's actually her, they have a Cher-off.

Jack (Sean Hayes) rebounds from his breakup with a new love.