Jack (Sean Hayes) tries to seduce Bill (Neil Patrick Harris) at a Welcome Back Home gathering for "ex-gay" people. Karen (Megan Mullally) tags along, hoping to make out with a woman.

Liz (Madonna) and Karen (Megan Mullally) were getting along just fine until a spat over a man in a bar throws their roomie arrangement into a tailspin.

Grace (Debra Messing) comes with Val (Molly Shannon) to her AA meetings to get free therapy and food, but things get ugly when Karen (Megan Mullally) forces Grace to tell the truth.

When Bobbi, Karen and Jack met for the first time, it was pure magic.

Jack makes a confession to his mother, and she makes a confession to him.

Watch the best of Will Truman (Eric McCormack) from Will and Grace and subsequently be jealous about how fast he can think on his feet.

During an iconic moment from Season 1, Will asks Grace if he's a bad gay man after returning home from a fight with Jack at the gym.

Jack (Sean Hayes), Karen (Megan Mullally) and Rosario (guest star Shelley Morrison) have an interesting visit with an I.N.S. officer (guest star Peter Paige).

Will, Grace, Jack & Karen all hangout at the White House, for very different reasons.

Will and Karen find themselves entwined in a love triangle after they both start sleeping with her pastry chef.

It's everyone's favorite Adler (sorry Grace) - Debbie Reynolds! Guest starring as Grace's mom throughout the series, this musical theatre legend had many a memorable moment - including singing some of her iconic showbiz hits on the show!

Following Ellen’s cancelation, many believed that any primetime show with a gay lead was cursed to fail.

Listen lady! Rosario was ICONIC on Will & Grace.

Grace's mom (played by the legendary Debbie Reynolds) drops by for a visit. Cue a tension headache...

No "Will & Grace" character was more savage than Karen. For this list, we’ll be looking at Karen’s fiercest moments and clap backs, and most ruthless remarks throughout the series’ run. Our countdown includes no one else matters, "better people," Rosa...